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In the first phase, a randomized, double-blind, crossover study was conducted in healthy adults ( n = 14) to assess whole-blood GSH following single oral doses using baseline-adjusted pharmacokinetic parameters (incremental AUC 0–24 [iAUC 0–24 ], C max , T max ) and a targeted panel of glutathione-related metabolites

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Clinical studies in deceased METH users with severe dopaminergic loss in the caudate have shown a 35% decrease in caudate GSH and a 58% increase in the oxidized form of GSH, GSSG [66]

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